Evidence map›Paper›PMID 40979790›Full record

ArticleWorld journal of emergency medicine2025

Genetic liability to atrial fibrillation, aortic valve disease, and mitral valve disease: a two-sample Mendelian randomization study.

Yun Zhang, Chengui Zhuo, Ting Chen, Xiaosheng Hu

Abstract read
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Article in World journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yun Zhang1Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Chengui Zhuo2Department of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, China.
Ting Chen1Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Xiaosheng Hu1Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch has revealed a relationship between atrial fibrillation (AF) and valvular heart disease; however, the causality remains largely unknown. This study explored whether a causal association between AF and non-rheumatic aortic valve disease (AVD) and mitral valve disease (MVD) could be found.

methodsA two-sample Mendelian randomization (TSMR) method was applied to determine the causal effect of AF on AVD, mitral regurgitation, and MVD. The inverse variance weighted (IVW) method was used as the primary analytical approach, and several complementary analyses were conducted. Outliers were detected using the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) and radial Mendelian randomization (MR) methods.

resultsGenetically predicted AF was found to be causally associated with the risk of MVD (odds ratio [

conclusionOur findings demonstrate a positive causal association between AF, MVD, and mitral regurgitation, but not AVD. Further research and an aggressive AF management strategy should be explored as potential measures for preventing MVD.

Indexed as

Atrial fibrillationMitral valve diseaseValvular heart disease

Identifiers

PMID40979790
PMCPMC12444237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.