ArticleIndian journal of anaesthesia2025
Impact of ageing on sevoflurane's hypnotic potency and induction kinetics during wash-in period: A prospective observational study.
Article in Indian journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: The age-dependent decline in sevoflurane's minimum alveolar concentration is well established. However, the relationship between ageing and its hypnotic potency at the effect-site concentration (Ceff) remains unclear. This study aimed to evaluate the impact of ageing on sevoflurane's hypnotic potency and induction kinetics during the wash-in period. Methods: This prospective observational study enroled 83 female patients stratified by age into four decades: 30-39, 40-49, 50-59, and 60-69 years. Anaesthesia was induced using 5% sevoflurane in a non-rebreathing manner. We continuously recorded bispectral index (BIS) values and end-tidal sevoflurane concentrations during the 4 min wash-in period, with Ceff values calculated through pharmacokinetic modelling. Subsequently, the end-tidal concentration was maintained at 1.5% for 20 min (10 min equilibration + 10 min stabilisation) at 2 L/min to achieve a cerebral steady-state, and the final stabilised BIS value was calculated. One-way ANOVA with Bonferroni post-hoc correction or Kruskal-Wallis test was used to compare continuous variables. Pearson's Chi-square test was used to compare categorical variables, with the significant difference set at Results: During the wash-in period, the 60-69-year group exhibited a prolonged time from awakening to BIS 50 compared to younger cohorts ( Conclusion: The hypnotic potency of sevoflurane is preserved among female patients aged 30-69 years despite delayed induction kinetics in older individuals.
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