Evidence map›Paper›PMID 40979743›Full record

ReviewOncology reviews2025

Protecting organs-at-risk in cancer therapies through temporary organ displacement: a comprehensive review.

Rance B Tino, Michael Li, Amirreza Heshmat, Ayush Suresh, AnaSimone Guillaume, Kristy K Brock, Bruno C Odisio, Eugene J Koay

Abstract readReview
In one paragraph

Review in Oncology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rance B TinoDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Michael LiDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Amirreza HeshmatDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Ayush SureshDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
AnaSimone GuillaumeDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Kristy K BrockDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Bruno C OdisioDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Eugene J KoayDepartment of GI Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Funding

Anatomical Modeling to Improve the Precision of Image Guided Liver AblationR01CA235564 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BROCK, KRISTY, ODISIO, BRUNO C · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA235564
6 · The paper itself

Abstract

Radiation therapy (RT) and locoregional ablation are cornerstones of modern oncology, yet their therapeutic potential is frequently limited by the challenge of sparing healthy organs-at-risk (OARs) from treatment-related complications. Temporary organ displacement (TOD) techniques directly address this issue by creating a physical separation using 'spacers' during treatment, thereby minimizing collateral damage while enhancing therapeutic precision. The clinical benefits, including improved tumor control, reduced morbidity, and enhanced survival, are documented across malignancies of the head and neck, thorax, abdomen, and pelvis. To create a unified framework for this evolving field, this comprehensive review provides a systematic classification of TOD techniques based on invasiveness, administration, device technology and the accompanying treatment mo`dality. Furthermore, we synthesize key historical and recent innovations, from non-invasive maneuvers to advanced surgical spacers, to contextualize current practices. Finally, we address barriers to standardization and highlight emerging concepts such as meta-materials, computational modeling, and digital twins, which provide promising avenues for enhancing personalized cancer care and patient outcomes.

Indexed as

dose toxicitynon-target organ injuryorgans-at-riskorgan sparingradiation therapyspacerstemporary organ displacementthermal ablation

Identifiers

PMID40979743
PMCPMC12447172

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.