ArticleJCPP advances2025
Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.
Article in JCPP advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Brain-heart coupling in tourette syndrome: a precision functional mapping study of discordant siblings.Frontiers in network physiology · 2026Article
- Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.JCPP advances · 2025Article
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9 authors.
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Abstract
Background: Tourette syndrome (TS) is associated with neuropsychiatric comorbidities, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). Even though comorbidities are the main source of impairment in individuals with TS, family aggregation between TS and other neuropsychiatric disorders has been little explored. We therefore investigated associations of tic severity in probands with symptoms of ASD, ADHD, and ODD in their siblings and the influence of tic severity, age, and sex. Methods: The sample of the present study stems from the European Multicenter Tics in Children Study (EMTICS), a longitudinal observational study, with the present subsample of 196 probands with TS and their 220 full siblings (54.1% girls). We analyzed associations of probands' tic severity with ASD, ADHD, and ODD symptoms in their siblings using generalized linear mixed-effect negative binomial regression models. Results: Higher tic severity in probands was associated with higher scores of ASD symptoms in their siblings (IRR = 1.48, 95% confidence interval [95% CI] 1.03-2.12, Conclusions: This multicenter study demonstrated a link between probands' current tic severity and siblings' neuropsychiatric symptoms. Our study suggests a familial link between TS and ASD-like symptoms, competencies as well as sex-specific associations with ADHD and ODD symptoms in female siblings. The current study sheds light on a broader family tendency and highlights the need for targeted prevention in this vulnerable population. Our findings, however, call for further studies to better understand the genetic and environmental aggregation of influences between individuals with TS, ADHD, and ODD and their siblings.
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