SynthesisFrontiers in endocrinology2025
Impact of the PPOS protocol on euploidy embryo rates and reproductive outcomes in preimplantation genetic testing cycles: a systematic review.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Progestogen-primed ovarian stimulation vs GnRH antagonists and/or agonists for women undergoing assisted reproduction: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Pooled it
- Medroxyprogesterone acetate vs. GnRH antagonist for preventing premature LH surge during ovarian stimulation in assisted reproductive technology: a retrospective cohort study.Frontiers in reproductive health · 2026Article
- Comparison of euploidy rates between progestin-primed ovarian stimulation and GnRH antagonist protocols: a single-center study in a mixed-ethnicity population.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The success of assisted reproductive technology (ART) relies on the quality of embryos, particularly the euploid status, which is influenced by controlled ovarian hyperstimulation (COH) protocols. In recent years, the progesterone-primed ovarian stimulation (PPOS) protocol has gained popularity due to its potential benefits. However, the impact of PPOS on euploid embryo rates (EER) and reproductive outcomes remains incompletely understood. Therefore, we conducted this review to comprehensively assess this impact by comparing the PPOS with conventional COH protocols in PGT cycles. The results revealed that the PPOS protocol demonstrated comparable EER and reproductive outcomes to conventional COH protocols in the general population. Among patients with a good prognosis, EER and associated reproductive outcomes with PPOS may be less favorable. However, in individuals with a poor prognosis, PPOS showed comparable or even superior outcomes. Additionally, the timing of cycle initiation, whether in the follicular or luteal phase, had no significant impact on clinical outcomes in patients with diverse ovarian responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.