Evidence map›Paper›PMID 40979721›Full record

ArticleFrontiers in endocrinology2025

Association between glycated hemoglobin and biomechanical properties of the skin with type 2 diabetes by using an electro-mechanical skin device.

Fei Chen, Jiahui Zhou, Xianxian Chen, Xuchen Deng, Jiangfeng Zhou, Xin Pan, Zimiao Chen, Xiaohua Gong

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In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fei ChenDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jiahui ZhouDepartment of Internal Medicine, The First People's Hospital of Longwan District, Wenzhou, Zhejiang, China.
Xianxian ChenDepartment of Internal Medicine, The people's hospital of Pingyang, Wenzhou, Zhejiang, China.
Xuchen DengDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jiangfeng ZhouWenzhou Medical University, Wenzhou, Zhejiang, China.
Xin PanDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zimiao ChenDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiaohua GongDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate the association between glycated hemoglobin (HbA1c) levels and biomechanical properties of the human skin with type 2 diabetes mellitus (T2DM) patients using an electro-mechanical skin device. Methods: A cross-sectional study enrolled 136 T2DM patients and 190 healthy controls. Biomechanical properties of the skin were measured with an electro-mechanical skin device(Khelometer Results: T2DM patients showed significantly higher F values and lower M, R, and H values compared to healthy controls. HbA1c levels were positively associated with F values and negatively associated with M, R, and H values across different skin sites. Participants with higher F values had significantly higher HbA1c levels. Restricted cubic spline analysis revealed strong nonlinear associations between HbA1c and skin biomechanical properties. Conclusions: The data indicate the electro-mechanical skin device is useful to quantitate the biomechanical properties of the skin. Furthermore, this study demonstrates a nonlinear relationship between HbA1c levels and the biomechanical properties of the skin. These findings add to the evidence to support the impact of elevated HbA1c on biomechanical properties in individuals with T2DM.

Indexed as

Diabetes Mellitus, Type 2Glycated HemoglobinSkinSkin Physiological PhenomenaAdultAgedBiomechanical PhenomenaCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedGlycated Hemoglobinhemoglobin A1c protein, humanelectro-mechanical skin deviceglycated hemoglobinskinskin biomechanical propertiestype 2 diabetes mellitus

Identifiers

PMID40979721
PMCPMC12447521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.