Evidence map›Paper›PMID 40979706›Full record

ArticleFrontiers in endocrinology2025

IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes.

Cintia Semzezem, Karla Fabiana Brasil Gomes, Aritania Sousa Santos, Pauline Brochet, Lindiane Gomes Crisostomo, Marcia Regina Soares Correia, Amanda Farage Frade-Barros, Luciano Abreu Brito, Maria Rita Passos-Bueno, Christophe Chevillard and 2 more

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

12 authors.

Cintia SemzezemLaboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Karla Fabiana Brasil GomesLaboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Aritania Sousa SantosLaboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Pauline BrochetFrench National Institute for Health and Medical Research (INSERM), Unité Mixte de Recherche (UMR) U1090, Aix Marseille University (AMU), Theories and Approaches of Genomic Complexity (TAGC), MarMaRa institute, Marseille, France.
Lindiane Gomes CrisostomoLaboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Marcia Regina Soares CorreiaLaboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Amanda Farage Frade-BarrosHeart Institute, Laboratory of Clinical Immunology and Allergy-LIM60- Instituto do Coração (INCOR), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Institute for Investigation in Immunology-iii/National Institute on Science and Technology (INCT), São Paulo, Brazil.
Luciano Abreu BritoDepartamento de Genética e Biologia Evolutiva, Instituto deBiociências da Universidade de São Paulo, São Paulo, Brazil.
Maria Rita Passos-BuenoDepartamento de Genética e Biologia Evolutiva, Instituto deBiociências da Universidade de São Paulo, São Paulo, Brazil.
Christophe ChevillardFrench National Institute for Health and Medical Research (INSERM), Unité Mixte de Recherche (UMR) U1090, Aix Marseille University (AMU), Theories and Approaches of Genomic Complexity (TAGC), MarMaRa institute, Marseille, France.
Edecio Cunha-NetoHeart Institute, Laboratory of Clinical Immunology and Allergy-LIM60- Instituto do Coração (INCOR), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Institute for Investigation in Immunology-iii/National Institute on Science and Technology (INCT), São Paulo, Brazil.
Maria Elizabeth Rossi da SilvaLaboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Although interleukin receptors have been implicated in various autoimmune diseases, their role in type 1 diabetes (T1D) remains underexplored and occasionally inconsistent. To evaluate the impact of polymorphisms in genes encoding the interleukin receptors IL-21R and IL-17RA on T1D susceptibility and other autoimmune manifestations, we analyzed 639 patients with T1D and 653 healthy controls. Methods: Selected variants in IL17RA (n=4), IL21R (n=4), were genotyped using the VeraCode GoldenGate assay (Illumina, USA). Autoantibodies were assessed by radioimmunoassay, ELISA, and a radiolabeled iodine receptor assay. Results: Two IL17RA variants were significantly associated with T1D: the rs2241049G allele was linked to increased susceptibility (OR=1.42; Discussion: These findings suggest that polymorphisms in IL17RA and IL21R genes may contribute to T1D pathogenesis and modulate the presence of pancreatic and extra-pancreatic autoantibodies.

Indexed as

Diabetes Mellitus, Type 1Genetic Predisposition to DiseaseInterleukin-21 Receptor alpha SubunitPolymorphism, Single NucleotideReceptors, Interleukin-17AdolescentAdultAutoantibodiesCase-Control StudiesChildChild, PreschoolFemaleGenotypeHumansMalePhenotypeAutoantibodiesIL17RA protein, humanIL21R protein, humanInterleukin-21 Receptor alpha SubunitReceptors, Interleukin-17extra-pancreatic autoantibodiesIL-17RAIL-21Rislet autoantibodiestype 1 diabetes

Identifiers

PMID40979706
PMCPMC12444888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.