ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2025
A comparative transcriptomic analysis at single-cell resolution reveals acral melanoma features distinct from cutaneous melanoma.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Single-cell profiling uncovers a hypoxia-vascular-immune axis underlying poor immunotherapy response in acral versus cutaneous melanoma.Journal of translational medicine · 2026Article
- Dissecting Melanoma Ecosystem Heterogeneity from Molecular Characteristics to Genetic Variation at Single-Cell Resolution.International journal of molecular sciences · 2025Article
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Abstract
Objective: Acral melanoma (AM), a unique subtype prevalent in China, develops on the palms, soles, and nail beds. Despite its distinct clinical and pathological features compared to cutaneous melanoma (CM), the molecular basis underlying these differences remains poorly understood. This study aims to perform a comprehensive comparative transcriptomic analysis of AM and CM at the single-cell level to uncover key molecular distinctions. Methods: We analyzed single-cell RNA sequencing (scRNA-seq) data from 39 AM patients and 18 CM cases. Single-cell transcriptomic profiling was used to compare tumor cell subpopulations and microenvironmental differences. Bioinformatics tools were employed for cell clustering, differential gene expression analysis, cell-cell communication network inferences, and survival analysis. Results: AM exhibited a significantly higher proportion of Conclusions: This study provides novel insights into the molecular distinctions between AM and CM, highlighting the critical role of
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