Evidence map›Paper›PMID 40979642›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Enhancing lentiviral production for WAS gene therapy: a comparative analysis of stable producer cell lines evaluating flatware system and adherent bioreactors in perfusion mode.

Parameswari Singh, Nikki Indresh Lal, Monica Terrao, Sarah Schwingal, Martina Biserni, Florian Aeschimann, Andrea Strauch, Herbert Dersch, Angel Jaramillo, Andreas Gille and 1 more

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parameswari SinghCSL Innovation GmbH, Marburg, Germany.
Nikki Indresh LalCSL Innovation GmbH, Marburg, Germany.
Monica TerraoCSL Innovation GmbH, Marburg, Germany.
Sarah SchwingalCSL Innovation GmbH, Marburg, Germany.
Martina BiserniCSL Behring, Research, Bern, Switzerland.
Florian AeschimannCSL Behring, Research, Bern, Switzerland.
Andrea StrauchCSL Innovation GmbH, Marburg, Germany.
Herbert DerschCSL Innovation GmbH, Marburg, Germany.
Angel JaramilloCSL Behring, Pasadena, CA, United States.
Andreas GilleCSL Behring, Pasadena, CA, United States.
Holger LauxCSL Innovation GmbH, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adherent bioreactorsex-vivo gene therapyhematopoietic stem cellslentivirus (LV)perfusion processstable packaging cell line (PCL)stable producer cell line

Identifiers

PMID40979642
PMCPMC12446366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.