ArticleCrystal growth & design2025
The Potential of Microwave Radiation and Mechanochemistry in the Formation of Purine Alkaloids Cocrystals Using Pyromellitic Acid as a Coformer: Synthesis, Structural, Spectroscopic, Thermal Analysis, and Biological Properties.
Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cocrystallization provides an efficient approach to modifying a wide range of physicochemical properties of active pharmaceutical ingredients (APIs), including solubility, dissolution rate, melting point, and hygroscopicity. Therefore, the development of effective and fast cocrystallization techniques is crucial for selectively obtaining a specific crystalline form. This study explores the potential of green chemical methods for synthesizing multicomponent cocrystals of theobromine (TBR) and theophylline (TPH) using pyromellitic acid (PMLA) as a coformer. Solution-based screening experiments with TBR resulted in the identification of a new TBR·PMLA 2:1 cocrystal. In the case of TPH, four new multicomponent forms were discovered, including two polymorphic TPH·PMLA 2:1 cocrystals (forms I and II) and two cocrystal solvates: TPH·PMLA·MeOH 2:1:2 and TPH·PMLA·H
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