ArticleFrontiers in neuroscience2025
Gray matter volume microstructural alterations in chronic post-burn pruritus: a voxel-based morphometry analysis using 3D T1-weighted imaging.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic post-burn pruritus (CPBP) refers to a highly prevalent as well as debilitating problem after burn injuries, substantially impairing patients' quality of life. Nevertheless, the precise pathological mechanisms underlying CPBP remain elusive. The present study seeks to investigate microstructural changes in gray matter among individuals with CPBP and to evaluate associations between these changes and clinical scale scores via voxel-based morphometry (VBM). Materials and methods: We recruited 20 people having CPBP and 20 healthy controls (HCs) who were of the same sex and age. T1-weighted imaging in three dimensions (3D-T1WI) was performed on each participant. Using VBM, volumes of gray matter in each region were measured. Volume differences between groups were measured, and it was methodically examined how the volume in particular brain regions correlated with clinical markers. Results: We found no discernible age difference between the groups ( Conclusion: The frontal, temporal, parietal, occipital, and cerebellar regions all exhibit a marked reduction in volume in response to CPBP.
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