Evidence map›Paper›PMID 40979529›Full record

ReviewFrontiers in neuroscience2025

Epigenetic remodeling: unveiling the potential endogenous mechanisms of exercise in alleviating neuropathic pain.

Hao Shan, Yuntao Xu, Jiabao Guo, Tong Li

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hao Shan *Department of Clinical Laboratory, Jiangsu Rongjun Hospital, Wuxi, Jiangsu, China.
Yuntao Xu *The Second School of Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiabao GuoThe Second School of Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Tong LiDepartment of Clinical Laboratory, Jiangsu Rongjun Hospital, Wuxi, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although exercise can improve neuropathic pain (NP), its underlying mechanisms have not been elucidated completely. Epigenetics involves the study of environmental factors, such as diet, temperature, and exercise, and basic functions. NP can be improved by controlling the state of epigenetic modification. This article focuses on the exercise and epigenetic mechanisms of NP and discusses the progress of the research on epigenetic regulation in the field of exercise rehabilitation. The studies presented herein are not only used to facilitate the understanding of the important potential mechanisms of exercise for improving NP but also provide a new idea that NP can be improved by endogenous regulatory mechanisms.

Indexed as

DNA methylationepigeneticexercisenerve injuryneuropathic pain

Identifiers

PMID40979529
PMCPMC12446320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.