Evidence map›Paper›PMID 40979520›Full record

ArticleJHLT open2025

Critical care management of right ventricular failure in pediatric left ventricular assist devices: An advanced cardiac therapies improving outcomes network (ACTION) endorsed statement.

Edon J Rabinowitz, Nancy Ghanayem, Lydia Wright, Amee M Bigelow, Shilpa V Govardhan, Tara M Neumayr, Tanya Perry, Meghna D Patel, Robert A Niebler, Kevin P Engelhardt and 7 more

Abstract read
In one paragraph

Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Edon J RabinowitzWashington University School of Medicine in St Louis, Division of Pediatric Critical Care Medicine, Department of Pediatrics and St Louis Children's Hospital, St. Louis, MO.
Nancy GhanayemUniversity of Chicago, Section of Pediatric Critical Care, Department of Pediatrics, Chicago, IL.
Lydia WrightDepartment of Pediatrics, The Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, OH.
Amee M BigelowDepartment of Pediatrics, The Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, OH.
Shilpa V GovardhanRady Children's Hospital, University of California San Diego, San Diego, CA.
Tara M NeumayrWashington University School of Medicine in St Louis, Division of Pediatric Critical Care Medicine, Department of Pediatrics and St Louis Children's Hospital, St. Louis, MO.
Tanya PerryDivision of Pediatric Critical Care, Cohen Children's Medical Center of New York, Northwell Health.
Meghna D PatelStanford University School of Medicine, Division of Pediatric Cardiology, Palo Alto, CA.
Robert A NieblerMedical College of Wisconsin, Department of Pediatrics and Children's Wisconsin, Herma Heart Institute, Milwaukee, WI.
Kevin P EngelhardtPhoenix Children's, Division of Pediatric Critical Care, Phoenix, AZ.
Isaura DiazVanderbilt University Medical Center, Department of Pediatrics, Division of Pediatric Critical Care, Nashville, TN.
Joseph PhilipUniversity of Florida Health, Department of Pediatrics, Division of Pediatric Cardiology, Jacksonville, FL.
Arene ButtoChildren's Healthcare of Atlanta, Division of Pediatric Cardiology, Atlanta, GA.
Iki AdachiDivision of Critical Care, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
David M PengDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI.
David KwiatkowskiStanford University School of Medicine, Division of Pediatric Cardiology, Palo Alto, CA.
Sebastian C TumeDivision of Critical Care, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The care of the right ventricle (RV) following left ventricular assist device (LVAD) implantation remains a major clinical challenge, with right ventricular failure (RVF) contributing significantly to morbidity and mortality. While much of the literature focuses on preoperative risk stratification and long-term management, there is limited guidance on the immediate postoperative period from a critical care perspective, particularly in pediatric patients. This review aims to provide practical guidance on the bedside management of the RV in the perioperative period following LVAD implantation in children with biventricular circulation, offering a framework for optimizing RV function and preventing failure. We discuss the pathophysiology of RVF in this setting, highlight key hemodynamic principles, and explore targeted interventions including volume management, inotropic and pulmonary vasodilator support, ventilatory strategies, mechanical circulatory support options, and strategies to mitigate secondary organ dysfunction. By addressing these pediatric-specific critical care considerations, we aim to assist bedside providers in optimizing outcomes for children undergoing LVAD implantation.

Indexed as

GuideLeft ventricular assist deviceMechanical circulatory supportMechanical ventilationPediatric cardiac critical careRight ventricular failureSubpulmonary failure

Identifiers

PMID40979520
PMCPMC12444162

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.