Metachronous nodal metastases from HPV-associated penile carcinoma in situ.

Ryan Antar, Brij Kathuria, Michael Wynne, Megan Clyne, Andrew Hall, Daniel Stein, Michael Whalen

Abstract readCase Reports

In one paragraph

Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan AntarDepartment of Urology, George Washington University School of Medicine, Washington, DC, USA.

Brij KathuriaDepartment of Urology, George Washington University School of Medicine, Washington, DC, USA.

Michael WynneDepartment of Urology, George Washington University School of Medicine, Washington, DC, USA.

Megan ClyneDepartment of Urology, Georgetown University School of Medicine, Washington, DC, USA.

Andrew HallDepartment of Pathology, George Washington University School of Medicine, Washington, DC, USA.

Daniel SteinDepartment of Urology, George Washington University School of Medicine, Washington, DC, USA.

Michael WhalenDepartment of Urology, George Washington University School of Medicine, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile intraepithelial neoplasia (PeIN) is a premalignant precursor of squamous cell carcinoma (SCC) with a 5-15 % risk of progression. Nodal metastasis without histologic invasion is exceedingly rare. We describe a 40-year-old man with recurrent, HPV-positive basaloid PeIN of the glans and distal urethra who developed right inguinal and pelvic nodal metastases despite serial resections consistently showing carcinoma in situ. Genomic profiling revealed EGFR and JUN amplifications with NCOR1 and PRKAR1A losses, alterations linked to aggressive tumor biology. This case highlights the paradoxical metastatic potential of high-grade PeIN and underscores the need for molecular risk stratification in surveillance and management.

Identifiers

PMID40979503

DOI10.1016/j.eucr.2025.103183

PMCPMC12444444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.