ArticleJournal of inflammation research2025
Study on the Effects of Tranexamic Acid on Perioperative Inflammation, Long-Term Functional Recovery, and Satisfaction in Total Knee Arthroplasty: A Follow-up Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Tranexamic Acid-Associated Hyaluronic Acid Exhibits Enhanced Oxidative Stability: A Comparative Rheological Study.Biomolecules · 2026Article
- Efficacy of NSAID Transdermal Patch for Postoperative Management in Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To explore the anti-inflammatory effects and safety of Tranexamic Acid (TXA) during the perioperative period of Total Knee Arthroplasty (TKA) in patients with Knee Osteoarthritis (KOA), and to follow-up on long-term knee joint function and patient satisfaction. Methods: A prospective non-randomized controlled cohort study evaluated TXA efficacy in 130 unilateral TKA patients with KOA between January 2019 and March 2021. Patients were randomized into TXA (n=65) and control (n=65) groups. The TXA group received both intravenous and intra-articular TXA as required Postoperative coagulation profiles, day-3 systemic inflammatory markers, 6-month DVT/complication rates, and 2-year functional outcomes (knee function, QoL [Quality of Life], satisfaction) were assessed. Results: No significant differences in demographics, clinical data, or KOA severity were observed between the control and TXA groups (P>0.05). Only TXA group showed decreased post-operative Fibrinogen (FIB) levels, while Erythrocyte Sedimentation Rate (ESR)(decreased to 15.41 ±4.39 mm/h), C-reactive Protein (CRP) (decreased to 33.32 ±11.56 mg/L), and Interleukin 6 (IL-6) levels significantly decreased (decreased to 111.38 ±30.14 μg/mL) on the third day post-operation (P<0.001). During the 6 months, specific complications did not significantly differ, but the overall complication rate notably decreased in the TXA group (OR=0.23, 95% CI 0.08 to 0.61, P = 0.012). At 2-year follow-up, TXA group showed significantly better joint function and QoL (P<0.05). Postoperative satisfaction correlated with preoperative TXA use, neutrophil count, NLR, ESR, and CRP. Multivariate analysis identified TXA as an independent predictor of satisfaction (P<0.05). TXA group exhibited reduced inflammation, lower complication rates, and improved long-term outcomes, demonstrating favorable perioperative and long-term outcomes in KOA management. Conclusion: TXA has a significant effect on perioperative inflammation, long-term functional recovery and satisfaction in TKA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.