ArticleLancet regional health. Americas2025
Risk factors and survival impact of severe radiation-related late toxicities in head and neck cancer-a cohort study.
Article in Lancet regional health. Americas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Nucleotide Metabolism in Health and Disease.MedComm · 2026Review
- Artificial intelligence (AI) for early identification of radiotherapy related toxicities from the electronic health records of patients with head and neck cancer.Clinical and translational radiation oncology · 2026Article
- VMAT for Head and Neck Cancer: What Is the Impact of the Optimization Parameters on the Treatment Plan Quality?Medical sciences (Basel, Switzerland) · 2026Article
- Late toxicities of head and neck radiotherapy.Lancet regional health. Americas · 2025Article
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Authors and funding
22 authors.
Funding
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Abstract
Background: Radiation late toxicities (RLTs) are complications of curative-intent radiotherapy (RT) for head and neck cancer (HNC) and are increasingly relevant due to younger age at diagnosis and improved survival outcomes. Methods: We conducted a cohort study of HNC patients who received ≥50 Gy as part of curative treatment between January 2003 and December 2020 at a Canadian quaternary cancer center. Risk factors for severe RLTs (≥RTOG Grade 3) were evaluated using time-to-event analyses. Actuarial rates of RLT and overall survival (OS) were estimated using competing risk and Kaplan-Meier methods, respectively. Cox proportional hazard models identified factors associated with RLT and OS. Findings: Among 7622 patients, 12.6% (n = 958) developed RLTs without disease progression, with a 5-year actuarial incidence of 16% (95% CI: 15-16). A Interpretation: RLTs are common and associated with worse survival among HNC survivors. Identification of modifiable risk factors provides opportunities for prevention. Multidisciplinary management of RLTs in specialized clinics may help improve the outcomes in this growing survivorship population. Funding: No external funding was utilized for this study.
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