ArticleFrontiers in veterinary science2025
Understanding the biochemical impact of leukoreduction on canine pRBC storage: a focus on reactive oxygen species and storage lesions.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Prestorage Leukoreduction of Canine Blood Products: A Critically Appraised Topic.Veterinary sciences · 2026Review
- Pilot Study: Association Between Surgical Severity and Postoperative Point-of-Care C-Reactive Protein Levels in Dogs Undergoing Orthopedic Surgery.Veterinary sciences · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transfusion therapy is vital for both humans and animals, though it poses significant risks, including the development of storage lesions in packed red blood cells (pRBCs). This study examines hematological and biochemical changes during the storage of canine pRBCs, focusing on intraerythrocytic reactive oxygen species (ROS) and the impact of pre-storage leukoreduction. Eleven pRBC units were each divided into two aliquots, resulting in a total of 22 units, eleven leukoreduced (LR-pRBC) and eleven non-leukoreduced (nLR-pRBC), which were analyzed over 42 days. Results showed increased hemolysis, lactic acidosis, and potassium efflux (All,
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