Outer Retinal Layer Assessment in Patients with Relapsing-Remitting Multiple Sclerosis: Multifocal Field Electroretinography and Optical Coherence Tomography.

Alaa A Meshref, Hanan Hosny, Hossam Khalil, Mona Hussein, Asmaa Samir, Rehab Elanwar, Rehab Magdy

Abstract read

In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alaa A MeshrefClinical Neurophysiology, Neuro Diagnostic Research Center (NDRC), Beni-Suef University, Beni-Suef, Egypt.

Hanan HosnyClinical Neurophysiology, Neuro Diagnostic Research Center (NDRC), Beni-Suef University, Beni-Suef, Egypt.

Hossam KhalilDepartment of Ophthalmology, Beni-Suef University, Cairo, Egypt.

Mona HusseinDepartment of Neurology, Beni-Suef University, Beni-Suef, Egypt.ORCID https://orcid.org/0000-0002-7478-7008

Asmaa SamirDepartment of Ophthalmology, Beni-Suef University, Cairo, Egypt.

Rehab ElanwarClinical Neurophysiology, Neuro Diagnostic Research Center (NDRC), Beni-Suef University, Beni-Suef, Egypt.

Rehab MagdyDepartment of Neurology, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-4916-276X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relapsing remitting multiple sclerosis (RRMS) may cause primary retinopathy, which reflects central nervous system atrophy. This study aimed to assess the outer retinal layers in RRMS patients with and without optic neuritis (ON) functionally by multifocal electroretinography (mf-ERG) and structurally by spectral-domain optical coherence tomography (OCT). This case-control study evaluated the eyes of 30 RRMS patients and 30 age - and sex-matched healthy subjects using mf-ERG and OCT. There was a significantly lower amplitude and delayed peak time of all five retinal rings in MS-ON and MS-non-ON eyes than in controls (

Indexed as

mf-ERGOCToptic neuritisouter retinaRRMS

Identifiers

PMID40979277

DOI10.1080/01658107.2025.2498406

PMCPMC12447836

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.