Evidence map›Paper›PMID 40979006›Full record

ArticleCureus2025

Effect of Negative Pressure Therapy on Skin Blood Flow Responses in Scar Tissue.

Wei-Cheng Shen, Hsu-Tang Cheng, Yih-Kuen Jan, Ben-Yi Liau, Chun-Ming Lien, Jian-Guo Bau, Wen-Hung Chao, Congo T Ching, Chi-Wen Lung

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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei-Cheng ShenDepartment of Creative Product Design, Asia University, Taichung, TWN.
Hsu-Tang ChengDepartment of Surgery, Asia University Hospital, Taichung, TWN.
Yih-Kuen JanDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, USA.
Ben-Yi LiauDepartment of Automatic Control Engineering, Feng Chia University, Taichung, TWN.
Chun-Ming LienDepartment of Commercial Design and Management, National Taipei University of Business, Taoyuan, TWN.
Jian-Guo BauDepartment of Agricultural Technology, National Formosa University, Huwei Township, TWN.
Wen-Hung ChaoDepartment of Cultural Creativity and Digital Marketing, National United University, Miaoli, TWN.
Congo T ChingGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, TWN.
Chi-Wen LungDepartment of Creative Product Design, Asia University, Taichung, TWN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSkin blood flow is crucial for transporting nutrients during healing and treating scarring. Negative-pressure therapy (NPT) is a promising option for enhancing skin blood flow. However, the most effective dosage of NPT for treating scars remains unclear. This study aimed to investigate the effect of different dosages of NPT on skin blood flow before and after treatment.

methodsIn this study, 36 participants with scars were recruited to assess the efficacy of various NPT interventions. NPT was administered at three different dosages: -105, -125, and -145 mmHg for 10 min. The perfusion level is defined as the amount of blood flowing through the skin (SBF). In NPT, SBF was measured before treatment (SBF-Baseline), during treatment (SBF-Application), and after treatment (SBF-Termination).

resultsSBF-Termination at -105 mmHg NPT (152.7 ± 33.7 perfusion units (PU)) showed a significantly higher SBF than at -125 mmHg NPT (77.5 ± 19.2 PU, P = 0.026) or -145 mmHg NPT (65.2 ± 12.7 PU, P = 0.012). Statistical relevance was found at -105 mmHg NPT between SBF-Application and SBF-Termination (r=0.890,P < 0.001).

conclusionThis study indicates that a -105 mmHg NPT dosage can effectively increase SBF. Our research contributes to the emerging field of scar treatment and provides evidence-based recommendations.

Indexed as

capillariescuppinglaser dopplerscartensile stresses

Identifiers

PMID40979006
PMCPMC12444002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.