ArticleCureus2025
A Comparative Evaluation of ABO Blood Group Antibody Titer Using Normal Saline, Low Ionic Strength Solution, and AB Plasma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Identification of a novel ABO*A1.01 allele with c.562C>T (p.Arg188Cys) mutation associated with ATransfusion · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Acute hemolytic transfusion reactions, hemolytic disorders in fetuses and neonates, and hemolysis in incompatible allogeneic hematopoietic stem cell transplantation are predominantly induced by antibodies in the ABO blood group system. Environmental factors appear to exert the most significant influence on the concentrations of isoagglutinin A and B antibody molecules, which may be classified as IgG, IgM, or IgA. The current study aimed to evaluate the ABO isoagglutinin A and B titers of whole blood donors. Methods This observational cross-sectional study was conducted at the All India Institute of Medical Sciences, Bhopal, India. We evaluated ABO isoagglutinin A and B titers in 199 healthy blood donors (Groups A, B, and O). Donor selection was based on national guidelines. Antibody titrations were performed using 0.9% normal saline (NS), low ionic strength solution (LISS), and AB plasma, followed by a comparative analysis. Results Antibody titration was done with all blood group donors with three different diluent media. Spearman's rank correlation coefficient (r) is used to assess the strength and significance of the relationship between titer measurements. A p-value under 0.05 was considered statistically significant for all analyses. A strong positive correlation was observed between NS and LISS (r = 0.828,
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Registered trials
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