ArticleCureus2025
Effect of General Anaesthesia Versus Brachial Plexus Block on Neutrophil Count, Neutrophil to Lymphocyte Ratio, and Platelet to Lymphocyte Ratio in Patients Undergoing Upper Limb Fracture Surgeries: A Randomized Clinical Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundHaematological parameters have emerged as a crucial biomarker for evaluating the immune response and systemic inflammation. This study evaluates the effect of anaesthesia technique on neutrophil count, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) in upper limb fracture surgeries. MATERIAL AND
methodsThis randomised clinical study was performed on 50 patients of 18 to 60 years of either sex with ASA physical status classification I and II undergoing upper limb fracture surgeries. They were equally divided into two groups: group A (GA) and group B (BPB). Neutrophil count, NLR, and PLR were recorded preoperatively, immediately after surgery, four hours, and 24 hours post-surgery. Result: NLR was elevated in both groups throughout the postoperative period, with consistently higher values in Group A compared to Group B. The mean neutrophil count (cells/µL) was significantly higher in Group A compared to Group B at both the immediate and four-hour postoperative intervals. Immediately after surgery, the neutrophil count was 5587.86 ± 612.76 in Group A and 5265.64 ± 309.89 in Group B. At 4 hours postoperatively, the count increased to 6248.62 ± 830.49 in Group A and 5578.34 ± 748.05 in Group B (p < 0.05). PLR was lower in Group A than in Group B immediately and four hours after surgery. At 24 hours postoperatively, PLR remained lower than preoperative values in both groups. In Group A, the mean PLR was 176.23 ± 49.10, and in Group B, it was 171.43 ± 62.15. Although the reduction was more pronounced in Group A, the difference was not statistically significant (p >0.05).
conclusionThis study concluded that GA increases neutrophil count and NLR, while PLR decreases compared to BPB. Adjusting anaesthetic techniques may reduce inflammation and improve recovery.
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