Evidence map›Paper›PMID 40978906›Full record

ArticleCureus2025

Heterotopic Pregnancy After Intracytoplasmic Sperm Injection With Viable Embryos: A Case Report and Literature Review.

Ioannis Boutas, Adamantia Kontogeorgi, Sofia-Maria Genitsaridi, Maria Sotiria Bompoula, Nektarios I Koufopoulos, Kyparissia Sitara, Dionysios T Dimas, Sophia Kalantaridou, Antonios Makrigiannakis, Magda Zanelli and 7 more

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ioannis BoutasDepartment of Obstetrics and Gynecology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, DEU.
Adamantia KontogeorgiThird Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Sofia-Maria GenitsaridiDepartment of Pediatrics and Neonatology, Agia Sofia Children's Hospital, Athens, GRC.
Maria Sotiria BompoulaThird Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Nektarios I KoufopoulosSecond Department of Pathology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Kyparissia SitaraDepartment of Internal Medicine, "Elpis" General Hospital of Athens, Athens, GRC.
Dionysios T DimasBreast Unit, Athens Medical Center, Psychiko Clinic, Athens, GRC.
Sophia KalantaridouThird Department of Obstetrics and Gynecology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Antonios MakrigiannakisDepartment of Obstetrics and Gynecology, University Hospital of Heraklion, Heraklion, GRC.
Magda ZanelliPathology Unit, Azienda Unità Sanitaria Locale Istituto di Ricovero e Cura a Carattere Scientifico (USL-IRCCS) di Reggio Emilia, Reggio Emilia, ITA.
Andrea PalicelliPathology Unit, Azienda Unità Sanitaria Locale Istituto di Ricovero e Cura a Carattere Scientifico (USL-IRCCS) di Reggio Emilia, Reggio Emilia, ITA.
Maurizio ZizzoSurgical Oncology Unit, Azienda Unità Sanitaria Locale Istituto di Ricovero e Cura a Carattere Scientifico (USL-IRCCS) di Reggio Emilia, Reggio Emilia, ITA.
Giuseppe BroggiDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia" Anatomic Pathology, University of Catania, Catania, ITA.
Serena SalzanoDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia" Anatomic Pathology, University of Catania, Catania, ITA.
Rosario CaltabianoDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia" Anatomic Pathology, University of Catania, Catania, ITA.
Annette HasenburgDepartment of Obstetrics and Gynecology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, DEU.
Roxana SchwabDepartment of Obstetrics and Gynecology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, DEU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterotopic pregnancy is defined as the simultaneous presence of gestation in two different sites, typically comprising an intrauterine pregnancy and an ectopic pregnancy. Due to the widespread use of assisted reproductive technologies (ARTs), the incidence of heterotopic pregnancies has increased significantly. A 36-year-old Caucasian woman, gravida 1, para 0, Rhesus positive, was referred to our hospital with a suspected ectopic pregnancy following her third in vitro fertilization with intracytoplasmic sperm injection cycle. The patient reported no vaginal bleeding or abdominal pain at the time of admission. Her medical history included dysmenorrhea, dyspareunia, and prior hysteroscopic removal of an endometrial polyp. She had no other significant medical, surgical, or family history. Transvaginal ultrasound confirmed the diagnosis of a heterotopic pregnancy. The patient underwent surgical management to address the ectopic component. The incidence of heterotopic pregnancy has risen in recent years due to the increased use of ARTs. In cases of tubal ectopic pregnancy, surgical intervention should be carefully considered, even when the risk to the coexisting intrauterine pregnancy cannot be entirely excluded.

Indexed as

ectopic pregnancyheterotopic pregnancyintrauterine pregnancyin vitro fertilizationrisk factors

Identifiers

PMID40978906
PMCPMC12446885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.