ArticleCureus2025
Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective facial cleansing is essential for removing dirt, oil, and impurities without compromising the skin barrier and hydration. However, many conventional cleansers contain harsh surfactants that may strip the skin of its natural lipids, leading to dryness, irritation, and barrier disruption.
aimThis study aimed to assess the safety and efficacy of a cleansing lotion containing cetyl alcohol and sodium cocoyl apple amino acids in eliminating skin surface impurities while preserving skin barrier function in healthy adult subjects with diverse skin types, including dry, oily, sensitive, combination, and normal.
methodsThis open-label, interventional study enrolled 27 participants, all of whom completed the 30-day study. The product's effectiveness was assessed through key clinical and instrumental evaluations, focusing on skin surface impurities by assessing porphyrin levels (size, value, and quantity) and skin tone, along with hydration, barrier function, and overall dry skin score.
resultsAfter 30 days of use, significant improvements were observed across all parameters. Skin surface impurities reduced, as evidenced by porphyrin size, quantity, and values reduced to 0.29 ± 0.23, 7.11 ± 4.96, and 130.30 ± 16.28, respectively. Overall skin tone improved to 22.78 ± 14.58, skin hydration improved to 46.07 ± 8.47, and barrier function improved to 9.27 ± 1.83, with all changes being statistically significant (p < 0.0001). No adverse event was reported during the conduct of the study.
conclusionThe soap-free cleansing lotion demonstrated clinical efficacy and excellent tolerability, effectively removing skin impurities while maintaining and enhancing skin hydration and maintaining the skin barrier function and overall skin appearance without causing irritation. These findings support its potential as a safe, evidence-based dermatological care, reinforcing its primary claims of effective cleansing and promoting visibly fresher and healthier skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.