ReviewCureus2025
Fragility Fractures of the Femur in Spinal Cord Injury Patients.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with spinal cord injury (SCI) experience rapid and profound bone loss below the level of injury, predisposing them to fragility fractures. Due to their frequency and clinical impact, femoral fragility fractures in SCI patients require special consideration. This literature review aims to summarize the current evidence on the epidemiology, pathophysiology, diagnosis, management, and prevention of femoral fragility fractures in SCI patients. A comprehensive literature search was conducted in Medical Literature Analysis and Retrieval System Online (MEDLINE) and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Studies focusing on femoral fractures in adults with SCI were included, while reviews, pediatric studies, animal studies, and non-English publications were excluded. Femoral fractures account for up to 61% of lower limb fractures in the SCI population, with the distal femur and hip being the most common sites. Risk factors include age, time since injury, motor-complete injuries, and low bone mineral density (BMD). Loss of BMD occurs rapidly after SCI and plateaus two to five years post-injury. Clinical presentation may be subtle, often requiring high suspicion and imaging. Operative management is favored over conservative approaches due to lower complication and non-union rates. Preventive strategies include early BMD assessment, vitamin D and calcium optimization, weight-bearing therapy, and pharmacologic agents such as bisphosphonates and denosumab. Femoral fragility fractures are among the most common and clinically significant complications in patients with SCI. Timely diagnosis, appropriate surgical management, and targeted prevention strategies are critical to reducing complications and maintaining function. There is a need for consistent screening protocols and further research to optimize care in this vulnerable population.
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Registered trials
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