Evidence map›Paper›PMID 40978808›Full record

ArticlebioRxiv : the preprint server for biology2024

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma.

Yang Yu, Yanling Zhao, Zhongcheng Shi, Feng Cheng, Larry L Wang, Jong Min Choi, Kan Li, Daniel Silverman, Dan Qi, Jun Wang and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yang YuCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Yanling ZhaoTexas Children's Hospital, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Zhongcheng ShiAdvanced Technology Cores, Baylor College of Medicine, Houston, TX 77030, USA.
Feng ChengCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Larry L WangDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA.
Jong Min ChoiSystems Onco-Immunology Laboratory, David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Kan LiDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, 08854, USA.
Daniel SilvermanCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Dan QiNeuroscience Institute and Department of Neurosurgery, Baylor Scott & White Health, Temple, TX 76502, USA.
Jun WangDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, 08854, USA.
Saurabh AgarwalDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Brian R RoodCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Jeffrey S DomeCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Muller FabbriCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Joanna S YiTexas Children's Hospital, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Erxi WuNeuroscience Institute and Department of Neurosurgery, Baylor Scott & White Health, Temple, TX 76502, USA.
Sung Yun JungDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Chunchao ZhangCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.
Jianhua YangCenter for Cancer and Immunology Research, Children's National Research Institute, Children's National Hospital, Washington, DC 20010, USA.

Funding

CAMKV Kinase Signaling in NeuroblastomaR01NS118008 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI YANG, JIANHUA · 2020 to 2024
$2.2M
NINDS NIH HHS R01 NS118008
6 · The paper itself

Abstract

Neuroblastoma (NB) can be a highly aggressive malignancy in children. However, the precise mechanisms driving NB tumorigenesis remain elusive. This study revealed the critical role of CREB phosphorylation in NB cell proliferation. By employing a CRISPR-Cas9 knockout screen targeting calcium/calmodulin-dependent protein kinase (CaMK) family members, we identified the CaM kinase-like vesicle-associated (CAMKV) protein as a kinase that mediates direct phosphorylation of CREB to promote NB cell proliferation.

Indexed as

Calcium/calmodulin-dependent protein kinasescyclic AMP response element-binding proteinNeuroblastoma

Identifiers

PMID40978808
PMCPMC12448073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.