ArticleFrontiers in medicine2025
Electro-acupuncture for long COVID neuropsychiatric symptoms: study protocol for a prospective, randomized sham-controlled, patient-assessor-blinded clinical trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Integrative perspectives on electroacupuncture modulation of vagal-cholinergic and neuro-immune-metabolic regulation in long COVID.Frontiers in integrative neuroscience · 2026Review
- Mechanism-Driven Translation of Electroacupuncture for Depression: Bridging the Gap Between Preclinical and Clinical Research.Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Patients recovering from long COVID often endure a spectrum of neuropsychiatric symptoms, including cognitive impairment, memory deficits, mood disturbances and sleep disorders, that significantly impact their quality of life. Acupuncture, particularly electroacupuncture, has shown promise in addressing these symptoms. Currently there is no high-quality clinical trial for acupuncture on long COVID neuropsychiatric symptoms. Methods and analysis: In this 24 weeks, sham-controlled, patient-assessor-blinded randomized trial, 150 long COVID patients will be equally allocated to either an electroacupuncture group (EAG) or a sham control group (SCG). Each subject will receive a total of 32 intervention sessions over a 16 weeks intervention phase (two sessions each week) and will be followed up for an additional 8 weeks. Primary outcomes include changes in the Mini-Mental State Examination (MMSE) and the Chinese version of the Beck Depression Inventory (CBDI) scores. Secondary outcomes include the Insomnia Severity Index (ISI), Brief Fatigue Inventory-Taiwan (BFI-T), and the Short Form 12 (SF-12). All outcomes will be assessed at baseline and then at 4 weeks intervals during both the treatment and post-treatment periods. Discussion: This trial aims to generate robust clinical data on the therapeutic effects of electroacupuncture for long COVID. The anticipated results will clarify electroacupuncture's value as a therapeutic option for neuropsychiatric symptoms in long COVID patients, contributing to evidence-based practice in integrative medicine.
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