ArticleClinical interventions in aging2025
Impact of Combined Cognitive and Physical Impairments on Long-Term Prognosis in Elderly Cardiovascular Disease Patients: A Prospective Cohort Study.
Article in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to evaluate the association between physical and cognitive function and long-term outcomes in elderly cardiovascular disease (CVD) patients, using the Short Physical Performance Battery (SPPB) and the Mini-Mental State Examination (MMSE). Patients and Methods: In this prospective cohort study, 524 patients aged ≥65 years hospitalized in the Department of Cardiology at Beijing Hospital from September 2018 to April 2019 were evaluated. Baseline demographic, clinical, laboratory, and functional data were collected, and physical and cognitive function were assessed using SPPB and MMSE scores. Patients were followed for all-cause mortality over a 5-year period. Kaplan-Meier survival analysis and Cox proportional hazards models were used to examine the mortality risk associated with impairments. Results: Physical impairment was identified in 28.2% and cognitive impairment in 12.4% of patients. The combination of both impairments was associated with a 5.47-fold increased mortality risk (HR: 5.47; 95% CI: 2.78-10.78; p<0.001). Each 1-point increase in SPPB and MMSE scores correlated with a 16.3% and 8.7% reduction in mortality risk, respectively. Cognitive function, particularly attention and calculation ability, has emerged as a significant predictor of survival. Conclusion: Combined physical and cognitive impairments are prevalent in elderly CVD patients and strongly predict poor long-term prognosis. Routine assessment of cognitive function alongside physical performance can improve clinical decision-making, intervention strategies, and patient management, offering the potential to enhance outcomes in this high-risk population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.