ArticleClinical interventions in aging2025
Prealbumin Adjusted Prognostic Nutritional Index May Predict the Postoperative Survival and Free Walking Abilities of Patients with Hip Fractures: A Multi-Center Follow-Up Study.
Article in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- NT-proBNP With Postoperative Complications and 2-Year Mortality Among Hip Fracture Patients: An Observational Cohort Study.Orthopaedic surgery · 2026Observational
- Nutrition-related clinical laboratory indicators in perioperative management of geriatric hip fractures: a narrative review from risk stratification to precision intervention.Frontiers in nutrition · 2026Review
- Establishment and validation of a clinical prediction model for perioperative pneumonia in elderly patients with hip fractures combined with preoperative stroke.Frontiers in medicine · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: This multi-center study aims to develop and validate the Prealbumin-adjusted Prognostic Nutritional Index (PAPNI), hypothesizing that it would enhance prognostic prediction for hip fracture patients compared to traditional indices. Methods: Data from 771 patients (Cohort 1) and 673 patients (Cohort 2) were retrospectively analyzed. The PAPNI was formulated by substituting albumin with prealbumin in the Prognostic Nutritional Index (PNI) formula, with its weight optimized using receiver operating characteristic (ROC) curves. All individuals were followed up for 1 year. The relationships between PAPNI and outcomes were explored. Results: In both cohorts, PAPNI demonstrated superior predictive accuracy for 1-year mortality and free walking ability compared to PNI, prealbumin, and lymphocyte count alone. Patients with low PAPNI exhibited significantly higher mortality rates and lower free walking rates. Multivariate analyses confirmed PAPNI as an independent predictor for outcomes of hip fracture. Conclusion: PAPNI, incorporating prealbumin, offers a more accurate and convenient method for predicting postoperative survival and functional recovery of hip fractures, providing a basis for early nutritional intervention.
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