Evidence map›Paper›PMID 40978653›Full record

ArticleBioinformation2025

Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses.

Lokesh Kumar Gurram, Rohan Hassan Chandrashekara, Ashok Nimmakanty Ramadas, Sushmitha Rameshbabu, Harinishri Thambi, Sarita Sunil Chammanam, Karrar Shaaban Imran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lokesh Kumar GurramDepartment of Internal Medicine, University Hospital of Wales (UHW), Heath Park Way, Cardiff, CF14 4XW, UK.
Rohan Hassan ChandrashekaraDepartment of Internal Medicine, Akash Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka 562110, India.
Ashok Nimmakanty RamadasDepartment of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India.
Sushmitha RameshbabuDepartment of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India.
Harinishri ThambiDepartment of Surgery, Madras Medical College, Chennai, Tamil Nadu, India.
Sarita Sunil ChammanamDepartment of General Medicine, JSS Academy of Higher Education and Research, Mysuru - 570 015, Karnataka, India.
Karrar Shaaban ImranDepartment of Medicine, University of Warith Al-Anbiyaa, Karbala Governorate, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.

Indexed as

autoimmune diseasems relapsesmultiple sclerosisrelapse managementserum 25-hydroxyvitamin dVitamin D deficiency

Identifiers

PMID40978653
PMCPMC12449534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.