Evidence map›Paper›PMID 40978559›Full record

ArticleClinical hematology international2025

Improving Advanced-Line Multiple Myeloma Care: Insights and Real-World Challenges from the EMMY Study.

Titouan Cazaubiel, Olivier Decaux, Bruno Royer, Denis Caillot, Arthur Bobin, Karim Belhadj-Merzoug, Margaret Macro, Laure Vincent, Aurore Perrot, Mohamad Mohty and 15 more

Abstract read
In one paragraph

Article in Clinical hematology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Titouan CazaubielDepartment of Hematology, Hôpital Haut Lévêque, University Hospital, Pessac, France.ORCID https://orcid.org/0009-0007-5834-5318
Olivier DecauxService d'hématologie clinique, UMR U1236, CHU de Rennes, Rennes, France.
Bruno RoyerImmuno-hématologie, Hôpital Saint Louis, APHP, Paris, France.
Denis CaillotHématologie Clinique, CHU Dijon, Dijon, France.
Arthur BobinHématologie, CHU Poitiers, Poitiers, France.
Karim Belhadj-MerzougUnité Fonctionnelle Hémopathies Lymphoïdes, Centre Hospitalier Universitaire Henri Mondor, Creteil, France.
Margaret MacroService d'hématologie clinique, Centre Hospitalier Universitaire de Caen, Caen, France.
Laure VincentCHU Montpellier - Hôpital St Eloi, Service d'hématologie clinique, Montpellier, France.
Aurore PerrotCHU Montpellier - Hôpital St Eloi, Service d'hématologie clinique, Montpellier, France.
Mohamad MohtyService d'Hématologie, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse - Oncopole, Université de Toulouse, Toulouse, France.
Lionel KarlinService d'Hématologie Clinique, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
Caroline JacquetService d'hématologie, CHU de Nancy - Hôpitaux de Brabois, Vandoeuvre les Nancy, France.
Laurent FrenzelService d'hématologie adulte - Responsable centre régional de traitement de l'hémophilie CRTH - Centre national de référence des mastocytoses CEREMAST, Hôpital Necker-Enfant Malade, Paris, France.
Thomas ChalopinService d'Hématologie et Thérapie Cellulaire, CHU Tours, Hôpital Bretonneau, Tours, France.
Cécile SonntagDépartement d'Hématologie et Oncologie, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre et Hôpital Civil, Strasbourg, France.
Jean FontanService Hématologie, CHRU Jean Minjoz, Besançon, France.
Sophie RigaudeauService d'Hématologie, CHV André Mignot, Université Versailles Saint-Quentin, France.
Cyrille TouzeauHematology Department, University Hospital Hôtel-Dieu, Nantes, France.
Hélène DemarquetteDepartment of Hematology, CH, Dunkerque, France.
Abdelaziz ChaibHemato-Oncologie et Medecine Interne, Centre Hospitalier du Pays d'Aix, Aix-en-Provence, France.
Clémence SantanaService Hématologie, Centre hospitalier de Valence, VALENCE, France.
Stéphane DarreDepartment of Hematology, CH Arras, Arras, France.
Benoit BareauHematology, Les Hôpitaux Privés Rennais Cesson Sévigné - Vivalto Santé, Cesson Sévigné, France.
Ronan GarlantézecSanté publique et épidémiologie, CHU de Rennes, Rennes, France.
Cyrille HulinDepartment of Hematology, Hôpital Haut Lévêque, University Hospital, Pessac, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Managing multiple myeloma (MM) patients receiving advanced (four or more) lines of treatment is a complex challenge. Therefore, real-world data are essential to better understand and address the medical need of this challenging population. We used the EMMY cohort, a French longitudinal real-world study, to describe the characteristics and outcomes of 2127 MM patients receiving advanced-line treatments between 2017 and 2020. A wide variety of treatments were used without a predominant combination showing an evolution over time. Patients exhibited median time to next treatment and overall survival ranging from 7.8 months (95% CI: 6.7-7.8) and 19.4 months (95% CI: 17.4-22.5) in Line 4 (L4) to 4.8 months (95% CI: 3.5-6) and 12.6 months (95% CI: 8.7-16.6) in L8, respectively. The EMMY study provides valuable insights into the real-world application of advanced-line treatments, demonstrating rapid disease progression and poor outcomes in these patients before the novel anti-B-cell maturation antigen (BCMA) directed therapies. These findings highlight the critical need for novel therapies in this population.

Indexed as

advanced linesmultiple myelomareal-world studyunmet medical need

Identifiers

PMID40978559
PMCPMC12449165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.