Evidence map›Paper›PMID 40978530›Full record

ArticleMolecular therapy. Nucleic acids2025

Targeting long non-coding RNA

Qiao Zhao, Loïs A K van der Pluijm, Morgane Gourvest, Atefeh Lafzi, Daniel Peled, Whitney G Rubin, Juliette A de Klerk, Roderick C Slieker, Leen M 't Hart, Wendy Stam and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Qiao ZhaoDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Loïs A K van der PluijmDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Morgane GourvestDepartment of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Atefeh LafziGraduate School of Informatics, Department of Health Informatics, Middle East Technical University, Ankara, Turkey.
Daniel PeledDepartment of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Whitney G RubinDepartment of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Juliette A de KlerkDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Roderick C SliekerDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Leen M 't HartDepartment of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Wendy StamDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Annemarie M van Oeveren-RietdijkDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Jacques M G J DuijsDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Angela KoudijsDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Joris I RotmansDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Hilal KazanDepartment of Computer Engineering, Antalya Bilim University, Antalya, Turkey.
Anton Jan van ZonneveldDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Coen van SolingenDepartment of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Roel BijkerkDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of integrity of the capillary network is directly associated with the development of kidney fibrosis resulting in chronic kidney disease. Here, we characterized long non-coding RNAs (lncRNAs) in endothelial cells (ECs) during the development of kidney fibrosis. Using a murine EC lineage-tracing model, we observed expression of the conserved lncRNA metastasis-associated lung adenocarcinoma transcript 1 (

Indexed as

antisense oligonucleotideschronic kidney diseaseendothelial cell functionkidney fibrosislong non-coding RNAsMALAT1MT: Non-coding RNAsRNA-therapeuticsvascular integrity

Identifiers

PMID40978530
PMCPMC12445227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.