ArticlePsychoradiology2025
Altered local gyrification index and corresponding functional connectivity in female depressed adolescents with suicide attempts and non-suicidal self-injury.
Article in Psychoradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mindful attention as a mechanism underlying non-suicidal self-injury: evidence from a longitudinal intervention trial.BMC psychiatry · 2026Trial
- Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study.Alpha psychiatry · 2026Article
- Neurobiological mechanisms and treatment of empathic pain in nonsuicidal self-injury.Frontiers in psychiatry · 2026Review
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Authors and funding
11 authors.
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Abstract
Background: Suicide attempts (SA) and non-suicidal self-injury (NSSI) are serious public health problems that frequently co-occur in adolescents females with major depressive disorder (MDD), yet their neurobiological distinctions remain unclear. Here, we sought to explore female adolescents' neural mechanisms via the local gyrification index (LGI) and resting-state functional connectivity (RS-FC) analysis. Methods: We compared scale scores, LGI, and seed-based RS-FC among three groups of female adolescents: MDD with both NSSI and SA (SA + NSSI, Results: Compared with the HC group, both SA + NSSI and NSSI groups showed significantly decreased LGI in the prefrontal cortex, including right rostral/caudal middle frontal gyrus (MFG), precentral gyrus and postcentral gyrus (po-CG.R), as well as left rostral MFG, precentral gyrus and opercular part of the inferior frontal gyrus. The brain regions with altered RS-FC (seeds based on po-CG.R and the rostral MFG.L) are mainly distributed in the anterior cingulate cortex, insula, postcentral gyrus, and occipital lobe ( Conclusion: Reduced cortical folding in postcentral and middle frontal gyri was found in both patient groups, alongside distinct functional connectivity, offering deeper neurobiological insights into SA and NSSI.
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