Evidence map›Paper›PMID 40978466›Full record

ReviewFrontiers in pharmacology2025

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications.

Angel T Alvarado, Amparo Iris Zavaleta, César Li-Amenero, María R Bendezú, Jorge A Garcia, Haydee Chávez, Juan J Palomino-Jhong, Felipe Surco-Laos, Doris Laos-Anchante, Elizabeth J Melgar-Merino and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angel T AlvaradoResearch Unit in Molecular Pharmacology and 4P Medicine, VRI, San Ignacio de Loyola University, Lima, Peru.
Amparo Iris ZavaletaMolecular Biology Laboratory of the Faculty of Pharmacy and Biochemistry of the National University of San Marcos, Lima, Peru.
César Li-AmeneroVictor Larco Herrera Hospital, Lima, Peru.
María R BendezúFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Jorge A GarciaFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Haydee ChávezFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Juan J Palomino-JhongFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Felipe Surco-LaosFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Doris Laos-AnchanteFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Elizabeth J Melgar-MerinoFaculty of Pharmacy and Biochemistry, San Luis Gonzaga National University, Ica, Peru.
Mario Bolarte-ArteagaHuman Medicine, Continental University, Lima, Peru.
Nesquen Tasayco-YatacoHuman Medicine, Faculty of Health Sciences, Norbert Wiener University, Lima, Peru.
Ricardo Pariona-LlanosFIA, Peruvian University of Applied Sciences, Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a neuropsychiatric disorder caused by neurochemical alterations, non-genetic, genetic, epigenetic and environmental factors. Pharmacoepigenetics studies the relationship between epigenetic variability and response to drugs. The objective was to realize a descriptive review of the current state of knowledge on epigenetic molecular mechanisms in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics drugs used in schizophrenia and their clinical implications. A brief description of the pharmacogenes

Indexed as

antipsychotic drugsclinical implicationsepigeneticspharmacogenesschizophrenia

Identifiers

PMID40978466
PMCPMC12443773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.