Evidence map›Paper›PMID 40978433›Full record

ArticleACS omega2025

Mechanistic Insights into the Anticancer Action of Novel 2‑Hydroxy-1,4-naphthoquinone Thiol Derivatives.

Thaís Barreto Santos, Alex de Souza Cruz Lopes Canuto, João Francisco Blaudt Virgilio de Carvalho Meira, Ana Caroline Santos-Diniz, Rafaella Machado de Assis Cabral Ribeiro, Caroline Reis Santiago Paschoal, Vitor Won-Held Rabelo, Paula Alvarez Abreu, Vitor Francisco Ferreira, David Rodrigues da Rocha and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thaís Barreto SantosInstitute of Chemistry,Universidade Federal Fluminense, Niterói, Rio de Janeiro 24020-141, Brazil.
Alex de Souza Cruz Lopes CanutoPostgraduate Program in Sciences Applied to Health Products, Faculty of Pharmacy, Universidade Federal Fluminense, Niterói, Rio de Janeiro 24241-000, Brazil.
João Francisco Blaudt Virgilio de Carvalho MeiraPostgraduate Program in Morphological Sciences, Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Ana Caroline Santos-DinizDepartment of Basic Sciences, Nova Friburgo Institute of Health (ISNF), Universidade Federal Fluminense, Nova Friburgo, Rio de Janeiro 28625-650, Brazil.
Rafaella Machado de Assis Cabral RibeiroInstitute of Chemistry,Universidade Federal Fluminense, Niterói, Rio de Janeiro 24020-141, Brazil.
Caroline Reis Santiago PaschoalPostgraduate Program in Pharmaceutical Sciences, Institute of Biodiversity and Sustainability, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro 27965-045, Brazil.
Vitor Won-Held RabeloInstitute of Biodiversity and Sustainability, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro 27965-045, Brazil.ORCID https://orcid.org/0000-0001-5303-6814
Paula Alvarez AbreuInstitute of Biodiversity and Sustainability, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro 27965-045, Brazil.
Vitor Francisco FerreiraDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Universidade Federal Fluminense, Niterói, Rio de Janeiro 24241-000, Brazil.
David Rodrigues da RochaInstitute of Chemistry,Universidade Federal Fluminense, Niterói, Rio de Janeiro 24020-141, Brazil.ORCID https://orcid.org/0000-0002-7928-8646
Bruno Kaufmann RobbsDepartment of Basic Sciences, Nova Friburgo Institute of Health (ISNF), Universidade Federal Fluminense, Nova Friburgo, Rio de Janeiro 28625-650, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cavity cancer, with squamous cell carcinoma (SCC) representing more than 90% of cases, remains a significant global public health challenge. Novel molecules are urgently needed to combat SCC while reducing adverse effects compared with current therapies. Naphthoquinones, a subgroup of quinones, exhibit diverse pharmacological activities, including antibacterial, antifungal, antiviral, anti-inflammatory, antiparasitic, and anticancer effects. In this study, we evaluated the cytotoxic potential of ten derivatives of α-xyloidone combined with thiols against oral SCC cell lines (SCC-4, SCC-9, and SCC-25). Although eight of these new thionaphthoquinone derivatives were effective against the sensitive SCC-9, only two compounds (

Identifiers

PMID40978433
PMCPMC12444508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.