Evidence map›Paper›PMID 40978430›Full record

ArticleACS omega2025

Loading Proteins into Extracellular Vesicles to Camouflage Protein Allergens.

Estella Rao, Angela Paterna, Valeria Longo, Noemi Aloi, Giorgia Adamo, Sabrina Picciotto, Daniele Romancino, Samuele Raccosta, Antonella Bongiovanni, Paolo Colombo and 1 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Estella RaoInstitute of Biophysics, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Angela PaternaInstitute of Biophysics, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Valeria LongoInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Noemi AloiInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.ORCID https://orcid.org/0000-0002-6424-8588
Giorgia AdamoInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.ORCID https://orcid.org/0000-0002-6887-763X
Sabrina PicciottoInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Daniele RomancinoInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.ORCID https://orcid.org/0000-0003-2041-0122
Samuele RaccostaInstitute of Biophysics, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Antonella BongiovanniInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Paolo ColomboInstitute for Biomedical Research and Innovation, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.
Mauro MannoInstitute of Biophysics, National Research Council of Italy, via Ugo La Malfa 153, Palermo 90146, Italy.ORCID https://orcid.org/0000-0001-9843-0428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell-derived membranous nanoparticles with a high potential as drug delivery systems due to their intrinsic capability to vehicle biological materials and information. Beyond the transport of small drugs and therapeutics, a biotechnological challenge consists of loading nanoparticles and macromolecules with large size, including antibodies and other proteins. Here, we use microalgal-derived EVs, named nanoalgosomes, that are biocompatible, sustainable, and green EVs derived from microalgae and thoroughly characterized in our previous work, and a recombinant calcium-binding protein (CBP), Par j 4, a minor allergen from

Identifiers

PMID40978430
PMCPMC12444598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.