Targeting Triple Negative Breast Cancer with a Dinuclear Copper(II) Thiocarbohydrazone Complex: Efficacy Evaluation and Cellular Response.

Kumudini Paliwal, Abinash Swain, Durga Prasad Mishra, Manjuri Kumar

Abstract read

In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Transmetalation in Cancer Pharmacology.International journal of molecular sciences · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kumudini PaliwalDepartment of Chemical Engineering, Birla Institute of Technology and Science Pilani, K.K. Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India.ORCID https://orcid.org/0000-0002-6985-3381

Abinash SwainCell Death Research Laboratory, Endocrinology Division, CSIR-Central Drug Research Institute, B.S. 10/1, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India.

Durga Prasad MishraCell Death Research Laboratory, Endocrinology Division, CSIR-Central Drug Research Institute, B.S. 10/1, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India.

Manjuri KumarDepartment of Chemical Engineering, Birla Institute of Technology and Science Pilani, K.K. Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India.ORCID https://orcid.org/0000-0002-8102-8923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of copper complexes in bioinorganic chemistry and medicinal chemistry has been thoroughly documented in the literature. In recent years, extensive studies have focused on copper complexes of Schiff bases that can bind to DNA and proteins, exhibiting significant cytotoxic activity against various cancer cell lines, paving the way for the development of novel copper-based anticancer therapeutics. In this regard, we have synthesized a new dinuclear Cu-(II) complex

Identifiers

PMID40978393

DOI10.1021/acsomega.5c04277

PMCPMC12444681

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.