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ReviewHealth science reports2025

Atypical Manifestations of Old World Cutaneous Leishmaniasis: A Systematic Review and Clinical Atlas of Unusual Clinical and Specific Anatomical Presentations.

Bahareh Abtahi-Naeini, Seyed Naser Emadi, Zabihollah Shahmoradi, Mahsa Pourmahdi-Boroujeni, Ali Saffaei, Fereshte Rastegarnasab

Abstract readReview
In one paragraph

Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bahareh Abtahi-NaeiniPediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital Isfahan University of Medical Sciences Isfahan Iran.ORCID https://orcid.org/0000-0003-1081-9477
Seyed Naser EmadiSkin Research Center of Razi and Imam Khomeini Hospital and Research Center for War-affected People Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-8247-8424
Zabihollah ShahmoradiSkin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran.ORCID https://orcid.org/0000-0001-6019-8985
Mahsa Pourmahdi-BoroujeniStudent Research Committee Isfahan University of Medical Sciences Isfahan Iran.ORCID https://orcid.org/0000-0003-4462-2883
Ali SaffaeiSkull Base Research Center, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-9563-924X
Fereshte RastegarnasabHypertension Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran.ORCID https://orcid.org/0000-0003-2366-7804

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Cutaneous leishmaniasis (CL) represents the most common form of leishmaniasis. It imposes a significant medical burden due to long-lasting ulcers and disfiguring scars, underscoring the need for comprehensive CL control strategies, particularly in endemic regions. This study aims to classify atypical CL presentations for clinical practitioners. Additionally, we compiled and categorized original images from our clinical encounters with CL to create a clinical atlas enhancing the existing literature. Methods: A systematic search for atypical manifestations of Old World CL was conducted in June 2023 via the PubMed database, utilizing MeSH-based keywords including leishmaniasis, atypical, manifestation, and characteristics. All of the records were included. Exclusion criteria included records published before the 20th century, non-English articles, review articles, nonclinical studies (experimental and epidemiological), studies focusing on New World CL (based on the study geographical location), or focusing on Post-Kala-Azar leishmaniasis. Relevant articles were selected and assessed. Results: Based on the clinical manifestations described in the selected studies, articles were classified into the following categories: (a) subacute CL, (b) chronic CL, (c) CL associated with lymphatic involvement, (d) CL associated with an immunocompromised state, and (e) cutaneous leishmaniasis on special anatomical sites. Clinical, diagnostic, and therapeutic facets were subsequently explored. Conclusion: The diagnosis of leishmaniasis can be challenging. Given the broadening spectrum of differential diagnoses for CL in clinical settings, dermatologists, pediatric dermatologists, internists, infectious disease specialists, and pediatricians must be aware of this classification of atypical CL.

Indexed as

atypicalclinical presentationleishmaniaold world cutaneous leishmaniasis

Identifiers

PMID40978310
PMCPMC12446576

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