Evidence map›Paper›PMID 40978282›Full record

ArticleInternational journal of particle therapy2025

Long-Term Tumor Control After Carbon Ion Radiation Therapy Boost in Locally Advanced Cervical Clear Cell Adenocarcinoma.

Amelia Barcellini, Alessandro Vai, Eloisa Arbustini, Marco Carnelli, Sara Imparato, Durim Delishaj, Carlo Pietro Soatti, Carmine Tinelli, Elisabetta Vitali, Viviana Vitolo and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of particle therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amelia BarcelliniDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Alessandro VaiMedical Physics Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy.
Eloisa ArbustiniCentre for Inherited Diseases, Department of Research, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Marco CarnelliGynecology and Obstetrics Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
Sara ImparatoRadiology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy.
Durim DelishajDepartment of Radiation Oncology, Alessandro Manzoni Hospital, Lecco, Italy.
Carlo Pietro SoattiDepartment of Radiation Oncology, Alessandro Manzoni Hospital, Lecco, Italy.
Carmine TinelliCNAO National Center for Oncological Hadrontherapy, Pavia, Italy.
Elisabetta VitaliRadiation Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
Viviana VitoloRadiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy.
Ester OrlandiRadiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell adenocarcinoma of the uterine cervix is a rare and aggressive subtype of cervical cancer, typically resistant to conventional radiation therapy and lacking dedicated treatment guidelines. We present the case of a young patient with an ataxia telangiectasia mutation and locally advanced disease, who was unfit for brachytherapy following standard chemoradiotherapy and subsequently received a carbon ion radiation therapy boost. This mixed-beam strategy was well tolerated and led to durable local control along with a nodal response, which is suggestive of a possible abscopal effect. These findings underscore the potential of carbon ion radiation therapy in overcoming radioresistance and suggest a contributory role of genetic background in mediating systemic immune effects.

Indexed as

Abscopal effectCarbon ion radiation therapyCervixClear cell adenocarcinoma

Identifiers

PMID40978282
PMCPMC12447221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.