Evidence map›Paper›PMID 40978205›Full record

ArticleClinical Medicine Insights. Oncology2025

Integrating Salivary Biomarkers CST4 and

Maryam Koopaie, Saba Manafi, Soheila Manifar, Shima Younespour, Sajad Kolahdooz, Mahdi Karimipour Pareshkooh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical Medicine Insights. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Systemic serological signatures and novel biomarker CST4 link CagA-positiveFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maryam KoopaieDepartment of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-9999-1443
Saba ManafiDepartment of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Soheila ManifarDepartment of Oral Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shima YounespourDentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sajad KolahdoozUniversal Scientific Education and Research Network (USERN), Tehran, Iran.
Mahdi Karimipour PareshkoohDepartment of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gastric cancer remains a leading cause of cancer-related death. Early detection is crucial, but effective non-invasive screening methods are lacking. This study investigates the diagnostic potential of salivary Cystatin S (CST4) and Methods: Forty-five patients with gastric cancer and 45 healthy controls participated in this case-control study. Saliva samples were collected and analyzed for CST4 and Results: Significant differences in salivary CST4 and Conclusions: The study highlights the potential of salivary biomarkers CST4 and

Indexed as

biomarkerscystatin S (CST4)gastric cancerhealth-related factorsmiR-223Saliva

Identifiers

PMID40978205
PMCPMC12449649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.