Evidence map›Paper›PMID 40978161›Full record

ArticleMaterials today. Bio2025

Bioactive recombinant human elastin gel for reconstructing elastic fibers and rejuvenating endogenously aged skin.

Yi Yang, Wenjie Huang, Jingjing Shi, Bei Tian, Caihong Fu, Jianxi Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi YangState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Wenjie HuangState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Jingjing ShiSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, PR China.
Bei TianState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Caihong FuState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
Jianxi XiaoState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous skin aging results in oxidative stress and degradation of elastic fibers, leading to reduced skin elasticity and dermal laxity. Current treatments rarely target elastic fiber regeneration. Here, we introduce a bioactive gel containing recombinant humanized elastin (RHE) that effectively restores skin elasticity and promotes extracellular matrix remodeling. RHE gel demonstrated superior efficacy in reversing UV-induced damage and oxidative stress in zebrafish models, and significantly improved skin function in aged mice, outperforming commercial vitamin E and recombinant humanized collagen (RHC) gels. Molecular analyses revealed enhanced expression of key elastic fiber and collagen components alongside reduced matrix-degrading enzymes. This study highlights RHE gel's potential as a novel therapeutic for regenerative dermatology and skin aging.

Indexed as

Antioxidant therapyECM regenerationElastic fibersRecombinant human elastinSkin aging

Identifiers

PMID40978161
PMCPMC12446672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.