Evidence map›Paper›PMID 40978143›Full record

ArticleiScience2025

Hybrid therapeutic agents for self-oxygenating wound therapy via infectious microenvironment modulation.

Taoyan Guo, Fei Yan, Jun Liu, Wenjing Li, Baolong Zhou, Huiling Li, Chao Zhang, Guanghui Pan, Lei Fan, Kun Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Taoyan GuoAffiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang 261053, Shandong, P.R. China.
Fei YanAffiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang 261053, Shandong, P.R. China.
Jun LiuWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.
Wenjing LiSchool of Pharmacy, Shandong Second Medical University, Weifang 261053 Shandong, P.R. China.
Baolong ZhouSchool of Pharmacy, Shandong Second Medical University, Weifang 261053 Shandong, P.R. China.
Huiling LiWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.
Chao ZhangWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.
Guanghui PanWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.
Lei FanWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.
Kun WangWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.
Bin WangAffiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang 261053, Shandong, P.R. China.
Xiaohua ZhaoSchool of Basic Medicine, Shandong Second Medical University, Weifang 261053 Shandong, P.R. China.
Shudong SunWeifangPeople's Hospital, Shandong Second Medical University, Weifang 261000, Shandong, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial enzymes mimicking natural processes offer promising solutions for treating infections, but their development faces challenges in synthesis complexity and therapeutic performance. We present a modular-assembly strategy to construct hierarchical MOF@COF heterostructures through covalent interface engineering, bypassing the need for function-specific monomer synthesis while amplifying functionality. By growing porphyrin-based COF shell on amino-functionalized Fe-MIL-88A MOF core, we achieved a morphology-controlled core-shell architecture with well-defined heterojunctions. This hybrid integrates the MOF's dual peroxidase- and catalase-like activities with the COF's photoactivity, enabling cascade therapeutic effects. MOF@COF selectively converts endogenous H

Indexed as

BioengineeringBiomaterialsComposite materialsEnzyme engineeringTissue Engineering

Identifiers

PMID40978143
PMCPMC12446510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.