ArticleFrontiers in oncology2025
Molecular clustering and prognostic features based on integrated databases predict survival and immune status in patients with gastric cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Development of a prognostic prediction model incorporatingJournal of gastrointestinal oncology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gastric cancer (GC) remains one of the most common malignancies worldwide with high mortality rates despite advances in treatment approaches. Patients frequently develop drug resistance to current therapies, highlighting the critical need for novel prognostic biomarkers that can enhance survival rates and guide immunotherapy decisions in patients with GC. Methods: We conducted a comprehensive bioinformatics analysis using integrated clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. GC cases were categorized into two prognostic-related gene (PRG) clusters, and differentially expressed genes were identified. We established a prognostic model based on 11 key genes, stratified patients into high-risk and low-risk groups, and developed a nomogram model for survival prediction. Expression of selected genes was validated through quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry in clinical samples. Results: The identified PRGs and gene clusters strongly associated with patient survival, immune system functions, and cancer-related pathways. Risk scores significantly correlated with immune cell abundance, checkpoint expression, and responses to immunotherapy and chemotherapy. For instance, the area under the curve (AUC) values of patients at 1-year, 3-year, and 5-year survival were all greater than 0.6 in the ROC curves ( Conclusion: Our research establishes a robust molecular signature for predicting survival of patients with GC and characterizing the tumor immune microenvironment. It aims not only to establish a prognostic model, but also to explore immunobiological functions. The identified prognostic features and key genes (CTHRC1, CST6, and AKR1B1) offer potential as biomarkers and therapeutic targets, potentially guiding more effective personalized treatment strategies for patients with GC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.