ArticleFrontiers in nutrition2025
Diagnostic value and mediation effects of the visceral adiposity index, triglyceride-glucose index, and platelet-to-HDL ratio in young overweight and obese Chinese adults.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Evidence on the combined diagnostic and mediating effects of visceral adiposity index (VAI), triglyceride-glucose index (TyGi), and platelet-to-HDL ratio (PHR) in young overweight and obese adults with metabolic syndrome (MetS) is limited. Methods: Overweight or obese patient from the Integrated Diagnosis and Treatment Center for Obesity were enrolled. Multivariable logistic regression was used to assess associations between the three markers and MetS severity. Receiver operating characteristic (ROC) analysis evaluated their diagnostic value, and mediation analysis explored their interrelationships. Results: Among 331 young adults (median age: 31 years; 60% female), the MetS prevalence was 30.2%. Levels of VAI, TyGi, and PHR were significantly higher in participants with MetS and were strongly associated with MetS severity. Their areas under the curve (AUCs) (VAI: 0.825, TyGi: 0.807, PHR: 0.683) outperformed that of waist circumference (0.604). While the combined use of all three markers yielded the highest AUC, it did not significantly exceed that of VAI alone. Mediation analysis revealed complex interrelationships: TyGi had the strongest total effect on MetS (43.3%, Conclusion: VAI, TyGi, and PHR are valuable diagnostic markers for MetS in young overweight and obese Chinese adults, with VAI showing the strongest predictive performance. Their interplay highlights the need for integrated interventions targeting visceral adiposity, insulin resistance, and inflammation to mitigate MetS progression. Clinical trial registration: https://www.chictr.org.cn/index.html, identifier ChiCTR2400082205.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.