ArticleEuropean heart journal. Case reports2025
Epinephrine and the paradox of Kounis syndrome: a case series and review of management.
Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Food-Associated Kounis Syndrome: Clinical Spectrum and Diagnostic Considerations from a Case Report and Systematic Qualitative Synthesis of Published Cases.Clinical reviews in allergy & immunology · 2026Pooled it
- Multiple bee stings leading to a delayed fatal coronary event with probable Kounis syndrome: a case report.International journal of emergency medicine · 2026Article
- Hornet Sting-Induced Type I Kounis Syndrome Presenting as a Non-ST-Elevation Acute Coronary Syndrome: A Case Report.Cureus · 2026Article
- Kounis Syndrome in the Modern Era: A Comprehensive Review of Allergic Acute Coronary Syndromes.Journal of clinical medicine · 2026Review
- Adrenaline-induced hypokalemia and critical QT prolongation in a patient with refractory anaphylactic shock complicated by myocardial ischemia: a case report.Annals of medicine and surgery (2012) · 2026Article
- Article
- Epinephrine in Kounis syndrome: life-saving treatment or cardiac risk?European heart journal. Case reports · 2025Article
- Authors' Reply: Adrenaline, Aspirin, and Corticosteroids Should Be Administered Mindfully While Treating Myocardial Infarction and Kounis Syndrome.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epinephrine, the primary treatment for anaphylaxis, may paradoxically worsen underlying myocardial ischaemia due to its vasoconstrictive effects and potential to trigger vasospasm during an inflammatory response. Case Summary: We present two cases of Kounis syndrome-one in a patient who developed Prinzmetal angina after exposure to shellfish and another who experienced cardiac arrest after receiving intramuscular epinephrine for an anaphylactic reaction to a wasp sting. Discussion: These cases emphasize the potential for anaphylaxis to precipitate acute coronary syndrome which can paradoxically be exacerbated by the routine administration of epinephrine in susceptible individuals, underscoring the importance of heightened vigilance and consideration of alternative therapies when Kounis syndrome is suspected.
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Registered trials
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