ArticleMaterials today. Bio2025
A comprehensive immune cycle enhancement strategy for alternative splicing-mediated endogenous Tumor neoantigens generation and delivery.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Enhancing targeted strategies for cancer immunotherapy by elucidating mRNA processing mechanisms.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although immunotherapy exhibits remarkable clinical potential for the treatment of tumors, immune responses generated by conventional approaches often fail to completely eradicate osteosarcoma. This inadequacy stems primarily from the low immunogenicity of osteosarcoma-derived neoantigens and the limitations of conventional strategies that focus on enhancing only a single step in the tumor immunity cycle and fail to effectively drive a comprehensive immune response. To address these challenges and augment antitumor immune responses, we developed the innovative core-shell nanoparticle system BaTiO3-indisulam@PD1-cell Membrane Nanoparticles (BI@PCM NPs). This system achieves tumor targeting and enables the ultrasound-triggered controlled release of components. Unlike traditional methods that rely on DNA damage-mediated neoantigen production, BI@PCM disrupts alternative RNA splicing, thereby generating high-quality Endogenous Tumor Neoantigens (ETNs). These ETNs are dynamically transported from the tumor site to lymph nodes (LNs) using BaTiO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.