Evidence map›Paper›PMID 40977829›Full record

ArticleGynecologic oncology reports2025

Landscape of genomic alterations and clinical outcomes in low-grade serous ovarian cancer in Korea.

Yu-Seon Shim, Ji Hyun Kim, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim

Abstract read
In one paragraph

Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-Seon ShimDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ji Hyun KimCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.
Sang-Soo SeoCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.
Sokbom KangCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.
Sang-Yoon ParkCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.
Myong Cheol LimCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To investigate the clinical characteristics, molecular findings, and survival outcomes of patients with low-grade serous ovarian cancer in Korea, with a focus on addressing the limited data on genetic profiling and targeted therapies in Asian populations. Methods: This study is a retrospective review of patients with pathologically confirmed LGSOC treated at the National Cancer Center Korea between 2010 and 2023. Patients underwent cytoreductive surgery and/or systemic or hormonal therapy. Molecular profiling included next-generation sequencing (NGS) of formalin-fixed, paraffin-embedded tumor samples and homologous recombination deficiency (HRD) testing. Survival outcomes were assessed using Kaplan-Meier analysis. Results: A total of 62 patients were included, with a median age of 41 years; 61.3 % presented with advanced-stage disease. BRCA mutations were detected in 6.4 % ( Conclusion: This study identifies frequent MAPK pathway mutations, including

Indexed as

BRAFHormone therapyKRASOvarian cancer

Identifiers

PMID40977829
PMCPMC12447911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.