ArticleFrontiers in public health2025
Global burden of skin cancer and its subtypes: a comprehensive analysis from 1990 to 2021 with projections to 2040.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mechanisms and therapeutic design of stimuli-responsive vesicular nanocarriers for melanoma.International journal of pharmaceutics: X · 2026Review
- MEL-IA: An Interoperable AI System for Multimodal Skin Lesion Classification in Hospital Settings.Journal of medical systems · 2026Article
- Targeting Skin Cancer with Natural Bioactive Compounds: From Molecular Mechanisms to Application Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Mycoendophytic-Derived Green Resveratrol-Conjugated Silver Nanoparticles Inhibit the Proliferation of Human Epidermoid Carcinoma A-431 Cells.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Community-Based Teledermatology for Urgent Suspected Skin Cancer: Health Economic Cost-Comparison and Discrete Event Simulation Study.JMIR dermatology · 2026Article
- From Ultrasound to Histopathology: Agreement Analysis and Depth Correction Model for Basal Cell Carcinoma Using a Portable 20 MHz High-Frequency Ultrasound Device.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Skin cancer represents a significant global public health concern. Comprehensive analysis of its global burden provides critical insights for evidence-based interventions. This study systematically evaluates the global disease burden of skin cancer and its subtypes. Methods: This study analyzed GBD 2021 data to assess ASIR and ASDR trends for total skin cancer and its subtypes (1990-2021), stratified by geography, age, and sex, using APC modeling, decomposition analysis, and inequality assessments, with projections through 2040. Results: First, skin cancer ASIR increased from 1990 to 2021, while ASDR significantly decreased. Second, geographical heterogeneity existed in distribution of histological subtypes. Third, skin cancer burden demonstrated age-dependent progression with compositional variance in subtypes across age groups. Fourth, sex disparities intensified beyond age 55, with increasing longitudinal divergence. Fifth, both the ASIR and ASDR of total skin cancer showed non‑linear associations with SDI. Sixth, international disparities in skin cancer burden demonstrated a decreasing trend. Finally, projections to 2040 indicate a continued increase in total skin cancer ASIR accompanied by a persistent decline in total skin cancer ASDR. Conclusion: ASIRs of total skin cancer and its subtypes showed increasing trends, while ASDRs demonstrated decreasing patterns, with significant heterogeneity across regions, age groups, and sex.
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