ReviewFrontiers in immunology2025
Palmitoylation in cancer: decoding its roles in signal transduction, tumor immunity, and emerging therapeutic opportunities.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Design, synthesis and network pharmacology-integrated evaluation of benzenesulfonamides as potential Dickkopf-1 (Dkk-1)-targeting anticancer candidates.RSC advances · 2026Article
- Pan-Cancer Multi-Omics Analysis Reveals the Potential of ZDHHC16 in Tumor Progression and Immune Regulation.Chemical biology & drug design · 2026Article
- Apoptotic Signaling Across Breast Cancer Subtypes and Cryoablation-Induced Tissue Injury.International journal of molecular sciences · 2026Article
- Integrative single-cell and bulk transcriptomics define cell death patterns and ZDHHC22 in gastric cancer progression.BMC medical genomics · 2026Article
- MXRA8, a key palmitoylation-related gene, promotes bladder cancer progression via remodeling tumor microenvironment and predicts poor prognosis.BMC urology · 2026Article
- Article
- The palmitoylation code in cell death signaling: from molecular mechanisms to therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Palmitoylation, a reversible post-translational modification involving the attachment of palmitic acid to cysteine residues of proteins, plays a critical role in the regulation of protein localization, stability, and function. Recent studies have revealed its significant involvement in various oncogenic processes, including tumor initiation, progression, metastasis, and immune evasion. This review comprehensively explores the molecular mechanisms of palmitoylation and its functional implications in different types of tumors. We discuss how palmitoylation modulates key signaling pathways such as Ras and Wnt/β-catenin, influencing tumor cell behavior and the tumor microenvironment. Additionally, we examine the impact of palmitoylation on anti-tumor immunity and its potential as a therapeutic target. Understanding the intricate roles of palmitoylation in cancer biology not only advances our knowledge of tumor pathogenesis but also opens new avenues for targeted cancer therapies. Future research directions and clinical applications are also highlighted to guide the development of novel interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.