Evidence map›Paper›PMID 40977711›Full record

ArticleFrontiers in immunology2025

Integrated transcriptomic and proteomic analysis of the immune response in

Jianlong Li, Tingxiang Luo, Zhen Ma, Depeng Yang, Sen Yang, Yongchang Li, Bayinchahan Gailike, Qingyong Guo, Zhengxiang Hu, Ercha Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianlong LiCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Tingxiang LuoCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Zhen MaCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Depeng YangCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Sen YangCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Yongchang LiCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Bayinchahan GailikeCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Qingyong GuoCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.
Zhengxiang HuCollege of Grassland Science, Xinjiang Agricultural University, Urumqi, China.
Ercha HuCollege of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: In the current study, transcriptomic and proteomic analyses on Results: In pairwise comparisons among the experimental groups, we identified 9,776 (SA/PBS), 10,230 (PM/PBS), and 1,309 (SA/PM) differentially expressed genes (DEGs), as well as 175 (SA/PBS), 277 (PM/PBS), and 223 (SA/PM) differentially expressed proteins (DEPs), respectively. Subsequent KEGG pathway analysis revealed that these DEGs and DEPs were significantly enriched in a range of pertinent pathways, including the immune system and apoptosis, Toll and IMD signaling pathways, MAPK signaling pathway, and NF - κB signaling pathway. The RT - qPCR detection data exhibited a concordant trend with the RNA - seq data, indicating a substantial alignment in the observed results. Notably, the defensin and lectin gene families emerged as potentially pivotal components within the innate immune defense system of ticks. Conclusion: Overall, in this study, genes, proteins, and signaling pathways integral to the immune defense of

Indexed as

Arthropod ProteinsIxodidaeProteomeStaphylococcus aureusTranscriptomeAnimalsGene Expression ProfilingProteomicsProteus mirabilisSignal TransductionArthropod ProteinsProteomeHyalomma anatolicumimmune defense mechanismimmune responseRNA-seqTMT-labeled quantitative proteomics

Identifiers

PMID40977711
PMCPMC12443844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.