ReviewFrontiers in immunology2025
Antigen-presenting cell internalization is key for understanding and evaluating therapeutic antibodies' immunogenicity.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Mechanisms of therapeutic antibodies immunogenicity: infliximab oligomeric aggregates increase T-cell response and uptake by dendritic cells involving mannose-sensitive receptor CD206.Frontiers in immunology · 2026Article
- Preclinical Nanoparticle Approaches Targeting Tumor-Associated Macrophages in Breast Cancer: From Mechanisms to Therapeutic Strategies.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic antibodies have revolutionized the treatment of many diseases. However, their safety and efficacy are often altered by their immunogenicity, as many patients frequently develop anti-drug antibodies. Dendritic cells (DCs) are the most potent antigen-presenting cells of the immune system. DCs initiate the immunogenic adaptive immune response by internalizing therapeutic antibodies using different pathways and receptors, leading to antigen presentation to T-cells. Recently, studies have shown that the uptake of antibodies by immune cells could contribute to their immunogenicity. This review will present in detail the different DC internalization mechanisms and then discuss the impact of therapeutic antibodies' properties and aggregation on their uptake by DCs and, therefore, their immunogenicity. We will also highlight cellular models and strategies used to evaluate antibodies' internalization. Addressing the uptake of antibodies by DCs could help to predict the risk of immunogenicity and to develop mitigation strategies.
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